We supply Supplement raw materials L-Carnitine-L-tartrate.
L-Carnitine-L-tartrate can be used for drugs and health products, sports beverage, infant
food and animal feed.
|Packing||In cardboard drum, 25kgs/drum(net wt)|
|Appearance||white crystal or crystalline powder|
There are two types of carnitine deficiency, primary and secondary
carnitine deficiency. Under these circumstances there is a specific
and scientific value of carnitine intake. Primary carnitine
deficiency is a genetic disorder of the cellular
carnitine-transporter system that typically appears by the age of
five with symptoms of cardiomyopathy, skeletal-muscle weakness, and
hypoglycemia. Secondary carnitine deficiencies may happen as the
result of certain disorders such as chronic renal failure, or under
conditions that reduce carnitine absorption or increase its
excretion, for example taking antibiotics, malnutrition, and poor
Some research has been carried out on carnitine supplementation in
athletes, given its role in fatty acid metabolism; however,
individual responses varied significantly in the 300 people
involved in one study.Carnitine has been studied in various
cardiometabolic conditions, with a bit of evidence pointing towards
efficacy as an adjunct in heart disease and diabetes. However,
there are insufficient trials to determine its efficacy.Carnitine
has no effect on preventing mortality associated with
cardiovascular conditions.Carnitine has no effect on serum lipids,
except a possible lowering of LDL.Carnitine has no effect on most
parameters in end stage kidney disease, however it possibly has an
effect on c-reactive protein. The effects on mortality and disease
outcome are unknown.
Carnitine provides additional source of energy rather than
carbohydrate metabolism by converting fats into energy in cellular
level which allow athletes to rely on their body fats as fuel as
well as carbohydrate intake. Also, the amount of carnitine in a
person’s system is related to the amount of glycogen found in the
muscles. So muscle carnitine prevents the use of glycogen in the
muscles. With this glycogen sparing effect, it becomes an
anti-catabolic agent that athletes could benefit from.
The carnitine content of seminal fluid is directly related to sperm
count and motility,suggesting that the compound might be of value
in treating male infertility. Several studies indicate that
carnitine supplementation may improve sperm quality,The reported
benefits may relate to increased mitochondrial fatty-acid oxidation
(providing more energy for sperm) and reduced cell death in the
Cardiovascular and peripheral arterial diseases
Several studies have approved the effectiveness of supplemental
carnitine in the management of cardiac ischemia (restriction of
blood flow to the heart) and peripheral arterial disease. In fact,
levels of carnitine are low in the failing heart muscle,
supplemental amounts might counteract the toxic effects of free
fatty acids and improve carbohydrate metabolism. Carnitine has had
anti-ischemic properties when given orally and by injection.
An important interaction between diet and the intestinal microbiome
brings into play additional metabolic factors that aggravate
atherosclerosis beyond dietary cholesterol. This may help to
explain some benefits of the Mediterranean diet. Hazen’s group from
the Cleveland Clinic reported that carnitine from animal flesh
(four times as much in red meat as in fish or chicken), as well as
phosphatidylcholine from egg yolk, are converted by intestinal
bacteria to trimethylamine (the compound that causes uremic breath
to smell fishy). Trimethylamine is oxidized in the liver to
trimethylamine N-oxide (TMAO), which causes atherosclerosis in animal models.
Patients in the top quartile of TMAO had a 2.5-fold increase in the
3-year risk of stroke, death, or myocardial infarction.
A key issue is that vegans who consumed L-carnitine did not produce
TMAO because they did not have the intestinal bacteria that produce
TMA from carnitine.
Chemotherapy and radiation treatment adverse effects such as
fatigue, mood and sleep disturbances, are common in cancer
patients. A deficiency in carnitine may also occur, some studies
were done on cancer patients with deficiency of carnitine.
Carnitine supplementation have showed normal blood levels of
carnitine, enhancement in mood and sleep, and relieving of the
fatigue caused by chemotherapy. Carnitine may be depleted in some
cancer chemotherapy treatments. There is weak evidence from
clinical trials that carnitine supplementation may be beneficial in
treating cancer anorexia-cachexia syndrome.
Type 2 diabetes which is marked by insulin resistance may be
associated with a defect in fatty acid oxidation in muscle. Several
studies suggest that carnitine supplementation may a beneficial
effect on glucose utilization and reduce diabetic neuropathy.
However carnitine may also increase overall cardio-metabolic risk.
Generally HIV infected patients accumulate fat in some areas of the
body and lose fat in other areas, besides having high blood levels
of fats (hyperlipidemia) and insulin resistance which is known as
the lipdystrophy syndrome. This syndrome causes a deficiency in L-
carnitine which causes defects in fat metabolism in mitochondria.
Supplementation with carnitine in HIV-infected individuals may slow
the death of lymphocytes, reduce neuropathy and favorably affect
blood lipid levels.
End stage renal disease and Hemodialysis
The kidneys contribute to overall homeostasis in the body,
including carnitine levels. In the case of renal impairment,
urinary elimination of carnitine increasing, endogenous synthesis
decreasing, and poor nutrition as a result of disease-induced
anorexia can result in carnitine deficiency. Carnitine blood levels
and muscle stores can become very low, which may contribute to
anemia, muscle weakness, fatigue, altered levels of blood fats, and
heart disorders. Some studies have shown that supplementation of
high doses of L-carnitine (often injected) may aid in anemia
|Identification||IR or nuclear magnetic resonance|
|Appearance||white crystal or crystalline powder|
|Specific rotation||-9.5~-11.0(10% aqueous solution)|
|pH-value||3.0~4.5(5% aqueous solution)|
|Residue on ignition||≤0.5%|